Western University, December 1, 2016
An HIV vaccine (SAV001) developed at Western University can now move on to Phase II human clinical trials. Plans are underway to test it in 600 HIV-negative subjects across North America as early as next fall. The Phase II trial, once approved by government regulatory agencies, will determine the vaccine’s ability to produce anti-HIV antibodies in patients who are not infected with the virus.
The results of the Phase I trial were published this week in the journal, Retrovirology, and showed that the vaccine is both safe for use and effective in triggering an anti-HIV immune response in HIV-positive patients. The results demonstrated that the vaccine was well tolerated with no serious adverse events and can now proceed to Phase II.
Developed by Chil-Yong Kang and a research team at Western’s Schulich School of Medicine & Dentistry, the vaccine was tested in 33 HIV-positive volunteers. The proposed next phase will involve 300 volunteers from the general population, and 300 from groups considered high-risk including men who have sex with men, intravenous drug users, sex workers, and those living with an HIV-positive partner.